Williamsville North upset South Park behind the play of Derick Isler, Zac Kelly and Nick Ames.
Eden upset Cheektowaga as Alex Smythe led the Raiders to a semi-finals matchup with Depew.
Akron moved on to the semi-finals as Austin Lauricella put the Tigers on his back while beating Southwestern.
Frontier scored the last 20 points including a TD in overtime by Cameron Coon to defeat Lockport in a come-from-behind win.
Randolph won its 19th consecutive game, defeating Dunkirk in non-league contest.
Grand Island dominated McKinley and will play Williamsville North on Saturday in a Class A Semi-final.
Sweet Home, Burgard and Cleveland Hill all recorded shutouts in the Section VI Quarterfinals.
Orchard park dominated Clarence behind the Quaker defense and the rushing of DeSean Walker.